About Me

I am a computational cancer genomics and pharmacogenomics researcher with 8+ years of research experience spanning microbiology, oncology, and precision medicine.

My work focuses on multi-omics data integration (RNA-seq / WES / WGS) and drug response profiling to identify biomarkers and mechanisms underlying therapeutic sensitivity and resistance in cancer, particularly pediatric acute leukemia.

I am currently transitioning fully into computational and data-driven biomedical research, with an emphasis on reproducible analysis pipelines and translational precision oncology.

Research Interests

• Computational cancer genomics
• Pharmacogenomics & drug response prediction
• Multi-omics data integration (RNA-seq, WES/WGS, drug sensitivity)
• Translational precision oncology

Projects

• RNA-seq Analysis Pipeline (End-to-End)
  Reproducible RNA-seq workflow including QC, alignment, quantification, differential expression, and visualization.
  🔗 GitHub: 202507_RNA-seq-analysis-pipeline

• Multi-omics Drug Response Analysis (ongoing)
  Integration of gene expression, genomic alterations, and drug sensitivity data to identify predictive biomarkers.

(More computational projects in progress — actively expanding GitHub portfolio.)

Selected Publications

Pediatric Acute Lymphoblastic Leukemia

• Tong PYG, Lin G, Li CK, et al.
  Pediatric Blood & Cancer, 2025. PMID: 39878315
  Homoharringtonine in Relapsed/Refractory Paediatric T-Cell Acute Lymphoblastic Leukaemia —
  A Case Series and a Report on the Use of In Vitro Drug Profiling.

• Zhang C, Chan KYY, Ng WH, Cheung JTK, Sun Q, Wang H, Chung PY, Cheng FWT, Leung AWK, Zhang X-B, Lee PY, Fok SP, Lin G, Leung KTL, et al.
  Haematologica, 2024. PMID: 38572553

Solid Tumor (Breast / Lung / Liver Cancer)

• Jiang YP, Liao WJ, Xin QL, Wang R, Lin G, Xu N, et al.
  Genes & Diseases, 2025. DOI: 10.1016/j.gendis.2025.101684
  Nuclear and cytoplasmic USP30-AS1 coordinately regulate breast cancer progression through HnRNPF/p21 and EZH2/c-Myc/p21 axes.

• Lin G, Li J, Xu N, et al.
  Journal of Cancer, 2021. PMID: 34659561
  RNA-binding protein MBNL2 regulates cancer cell metastasis through miR-182–MBNL2–AKT.

• +3 additional peer-reviewed papers (PMID: 33466733; 34948132; 31534127)

Microbiology (Aspergillus flavus)

• Zhang M, Lin G (equal contribution), Zhuang Z, et al.
  IMA Fungus, 2021. PMID: 34006318
  The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus.

• +2 additional peer-reviewed papers (PMID: 30264213; 30036940)

Skills

• Programming & Data: R, Python, Linux, HPC
• Bioinformatics: RNA-seq, WES/WGS, differential expression, drug response analysis
• Analysis: Multi-omics integration, biomarker discovery, clinical-genomic association
• Experimental (background): PDX models, CRISPR, flow cytometry, drug screening

Education

• Ph.D. in Medical Sciences
  The Chinese University of Hong Kong

• M.Sc. in Precision Medicine and Healthcare
  Tsinghua Shenzhen International Graduate School, Tsinghua University

• B.Sc. in Biological Sciences
  Fujian Agriculture and Forestry University

Honors & Awards

• ASH Abstract Achievement Award, ASH Annual Meeting, 2023
• Selected oral/poster presentations at international conferences